What Is The Most Fatal Disease?

1. Ischemic heart disease, or coronary artery disease – The deadliest disease in the world is coronary artery disease (CAD). Also known as ischemic heart disease, CAD occurs when the blood vessels that supply blood to the heart become narrowed. Untreated CAD can lead to chest pain, heart failure, and arrhythmias.

Impact of CAD worldwide. Although it is the leading cause of death, mortality has decreased in many European countries and in the United States. This could be due to public health education, access to healthcare and better forms of prevention. However, in many developing countries, death rates from CAD are increasing.

Increasing life expectancy, socioeconomic change, and lifestyle risk factors play a role in this increase. Risk factors for CAD include: High blood pressure High cholesterol Smoking Family history of CAD Diabetes Being overweight Talk to your doctor if you have one or more of these risk factors.

Which disease is permanent?

Chronic diseases are defined broadly as conditions that last 1 year or more and require ongoing medical attention or limit activities of daily living or both. Chronic diseases such as heart disease, cancer, and diabetes are the leading causes of death and disability in the United States.

Tobacco use and exposure to secondhand smoke, Poor nutrition, including diets low in fruits and vegetables and high in sodium and saturated fats. Physical inactivity, Excessive alcohol use,

What are the 5 killer disease?

This paper highlights five killer diseases- diarrhoea, measles, whooping cough, tetanus and fever.

Can you ever get rid of a disease?

Disease eradication is the holy grail for health officials, as eradication of disease and better health ultimately benefits ecosystems on a global level. Initiatives such as One Health, embraced by the Centers for Disease Control and Prevention (CDC), aim to integrate human health, animal health and environmental factors when tackling disease prevention, treatment and eradication.

One Health considers the impact that climate change, increased human presence in previously unpopulated locations, increased human-animal interactions and global human and animal migration have on the spread of disease. To date, the World Health Organization (WHO) has declared only 2 diseases officially eradicated: smallpox caused by variola virus (VARV) and rinderpest caused by the rinderpest virus (RPV).

Smallpox was an ancient disease that caused epidemics throughout human history, resulting in 300-500 million deaths (an estimated 10% of all deaths) in the 20th century, Rinderpest was a deadly bovine disease causing the deaths of cattle herds throughout Europe and Africa from the 18th to the 20th century, until a dedicated global campaign led to its eradication. Smallpox blisters on arm (NCP 10520), National Museum of Health and Medicine. Cows Killed by rinderpest in South Africa, 1896.

What is the #1 chronic disease?

Number 1: Hypertension (high blood pressure) The danger of hypertension is not only that you can have it for years and not know it, but it can cause other serious health conditions, like stroke and heart attacks.

What is a serious illness?

Systems Enhancements – Patient Identification: Moving towards universal access to high-quality serious illness care first requires recognition of patients with serious illness as a defined population. Amy Kelley, MD, and others have proposed the following definition: Serious illness is a health condition that carries a high risk of mortality and either negatively impacts a person’s daily functioning or quality of life or excessively strains his or her caregivers.

1. While numerous approaches to identifying this population have been explored, so far they tend to be better at identifying patients who are closer to death, after multiple hospitalizations or significant functional decline.
2. We need more inclusive approaches that allow patient identification to occur earlier on the illness continuum.

At the same time, inclusion criteria need to be narrow enough that it is realistic for busy clinicians to focus enhanced attention of this population. Although various approaches exist (e.g., The Surprise Question ), none are optimal, and population- and needs-based patient identification remains a significant challenge for our field. Study selection for the systematic review. SQ = surprise question, SQ− = response to SQ is yes. CMAJ.2017 Apr 3; 189(13): E484–E493. Electronic Health Reports Optimization: Our EHRs fail to support high-quality serious illness care:, they neither mandate recording of essential clinical information (such as functional and cognitive status and patient priorities for care) nor do they standardize the recording of and access to the information necessary to support patient identification, management, communication, and coordination.

Most relevant information, if recorded at all, is found in progress notes, making it burdensome to access. Clinicians have not been trained to use the capacities that do exist in the EHR. Palliative care clinicians can lead their institutions in advocating for and implementing a “single source of truth” for all advance care planning information in the EHR, and in training their colleagues about the value of collecting and reliably recording this information in one place.

Measurement: Population-level measurements for patients with serious illness can guide systems in patient identification, needs assessment, and care improvement. Using both prospective identification (e.g., The Surprise Question) and retrospective identification (e.g., institutionally-collected data about patient deaths, state death data) is essential to this process.

Palliative care leaders should assess the availability of data about in-hospital and out-of-hospital deaths of patients cared for by their system, and begin the process of collecting a registry of all deaths that meet certain criteria (e.g., all patients seen in the system hospitals or clinics two or more times in the six months before death) to enable both assessment of current state and improvement.

Such data will allow systems to answer such questions as: What proportion of our seriously ill patients was seen by palliative care? What proportion had a health care proxy? A documented conversation about values and goals? A MOLST or POLST form in the EHR? How many were in a hospital or ED in the last months of life, and how many times and for how long? Such data provide a road map for improvement efforts.

What are lifetime diseases?

Lifestyle diseases are ailments that are primarily based on the day to day habits of people. Habits that detract people from activity and push them towards a sedentary routine can cause a number of health issues that can lead to chronic non-communicable diseases that can have near life-threatening consequences.

Non communicable diseases (NCDs) kill around 40 million people each year, that is around 70% of all deaths globally.1 NCDs are chronic in nature and cannot be communicated from one person to another. They are a result of a combination of factors including genetics, physiology, environment and behaviours.

The main types of NCDs are cardiovascular and chronic respiratory diseases in addition to cancer. NCDs such as cardiovascular diseases (CVD), stroke, diabetes and certain forms of cancer are heavily linked to lifestyle choices, and hence, are often known as lifestyle diseases.

1. Cardiovascular diseases that include heart attacks and stroke account for 17.7 million deaths every year, making it the most lethal disease globally.
2. Cancer kills around 8.8 million people each year, followed by respiratory diseases that claim around 3.9 million lives annually and diabetes that has an annual morbidity rate of 1.6 million.

These four groups of diseases are the most common causes of death among all NCDs.2 Figure 1 depicts the top 10 causes of death globally. NCDs are caused, to a massive extent, by four behavioural risk factors: tobacco use, unhealthy diet, insufficient physical activity and harmful use of alcohol.3 According to WHO, low- and middle-income countries and the poorer people in all countries are the worst affected by deaths due to NCDs.

1. It is a vicious cycle of risk where the poor are increasingly exposed to behavioural risk factors for NCDs and, in turn, such diseases may play a significant role in driving people and their families towards poverty.
2. It starts from an individual and eventually affects entire countries.
3. A country like India, for example, was slated for an economic loss of more than $236 million in 2015, on account of unhealthy lifestyles and faulty diet.4 That is why in order to tackle the global impact of NCDs, it has to be aggressively confronted in the most affected areas and communities.

Characteristics of NCDs Complex etiology (causes): Non communicable diseases are driven by seemingly unrelated causes such as rapid unplanned urbanization, globalization of unhealthy lifestyles and population ageing. Apparent causes such as raised blood pressure, increased blood glucose, elevated blood lipids and obesity may be representations of deep lying lifestyle habits.5 Multiple risk factors: There are a number of risk factors that lead to the onset and development of NCDs.

• The various types of risks can be divided into three primary risk sets: modifiable behavioural risk factors, non-modifiable risk factors and metabolic risk factors, many of which are common for a number of diseases.
• Long latency period: The latency period of NCDs is generally long, often stretching from many years to several decades.

Non-contagious origin (noncommunicable): NCDs are not communicated from one person to another, so it is a given that these diseases develop in a person from non-contagious origins. Prolonged course of illness: NCDs are chronic in nature and thus the course of illness if often prolonged and takes years before a patient may be forced to opt for medical care or intervention.

1. Functional impairment or disability: NCDs usually give rise to circumstances that make it difficult for the patients to lead a normal life.
2. Patients with chronic NCDs may not be able to take part in regular physical activity, go to the office or eat normally.
3. Causes The causes of NCDs can be divided into three broad categories: modifiable behavioural risk factors, non-modifiable risk factors and metabolic risk factors.

Modifiable behavioural risk factors: Behavioural risk factors such as excessive use of alcohol, bad food habits, eating and smoking tobacco, physical inactivity, wrong body posture and disturbed biological clock increase the likelihood of NCDs. The modern occupational setting (desk jobs) and the stress related to work is also being seen as a potent risk factor for NCDs 6,

• According to the WHO, more than 7 million people die each year due to the use of tobacco and the fatality rate is projected to increase markedly in the years to come.
• Excessive use of sodium in the diet causes 4.1 million deaths per year while alcohol intake leads to around 1.65 million deaths due to NCDs.

A simple lack of physical activity has been claiming 1.6 million lives annually.1 Non-modifiable risk factors: Risk factors that cannot be controlled or modified by the application of an intervention can be called non-modifiable risk factors and include:

Age Race Gender Genetics

Metabolic risk factors: Metabolic risk factors lead to four major changes in the metabolic systems that increase the possibility of NCDs:

Increased blood pressure Obesity Increased blood glucose levels or hyperglycemia Increased levels of fat in the blood or hyperlipidemia

Increased blood pressure is the leading metabolic risk factor globally with 19% of the global deaths attributed to it, followed by obesity and hyperglycermia.1 WHO (2017). Noncommunicable diseases. Fact Sheet. (Retrieved from: http://www.who.int/mediacentre/factsheets/fs355/en/ on: 2/05/2017) 3 WHO (2011).

• Global status report on noncommunicable diseases 2010.
• Retrieved from http://www.who.int/nmh/publications/ncd_report_full_en.pdf on 1/05/2017) 4 WHO/WEF (2008).
• Preventing noncommunicable diseases in the workplace through diet and physical activity: World Health Organisation/World Economic Forum report of a joint event.5 Aryal KK, Mehata S, Neupane S, Vaidya A, Dhimal M, et al.

(2015). The Burden and Determinants of Non Communicable Diseases Risk Factors in Nepal: Findings from a Nationwide STEPS Survey. PLoS ONE, 10 (8), e0134834.6 Sharma M, Majumdar PK (2009). Occupational lifestyle diseases: An emerging issue. Indian Journal of Occupational and Environmental Medicine, 13(3), 109–112.

Ischaemic heart disease Stroke Peripheral arterial disease Congenital heart disease

CVDs are the number 1 cause of death globally and account for more than 17 million deaths per year. The number is estimated to rise by 2030 to more than 23 million a year.7

Major Modifiable Risk Factors	Non-Modifiable Risk Factors	Other Risk Factors
High blood pressure Abnormal blood lipids Tobacco use Physical inactivity Obesity Unhealthy diet (salt) Diabetes Heavy alcohol use	Age Heredity or family history Gender Ethnicity or race	Excess homocysteine in blood – Inflammatory markers (Creactive protein) Abnormal blood coagulation (elevated blood levels of fibrinogen) Lipoprotein(a)

Diabetes Diabetes is a metabolism disorder that affects the way the body used food for energy and physical growth. There are 4 types of diabetes: Type 1, Type 2, Gestational, and Pre-Diabetes (Impaired Glucose Tolerance). Type 2 is the most common diabetes in the world and is caused by modifiable behavioural risk factors.

Major Modifiable Risk Factors	Non-Modifiable Risk Factors	Other Risk Factors
Unhealthy diets Physical Inactivity Obesity or Overweight High Blood Pressure High Cholesterol Heavy alcohol use Psychological stress High consumption of sugar Low consumption of fiber	Advacnced age Family history/genetics Race Distribution of fat in the body	Presence of autoantibodies Low socioeconomic status

Cancer Cancer affects different parts of the body and is characterised by a rapid creation of abnormal cells in that part and can invade other parts of the body as well. More than 7 million people die of cancer each year and 30% of those diseases are attributed to lifestyle choices.8

Type Of Cancer	Modifiable Risk Factors	Other Risk Factors
Cervical cancer	Smoking Poverty Human papilloma virus infection (hpv)	Immune deficiencies Family history
Lung cancer	Smoking Second hand smoke Radiation therapy Being exposed to asbestos, radon, chromium, nickel, arsenic, soot, or tar Living in air-polluted place
Breast cancer	Hormone therapies Weight and physical activity	Race Genetics BRCA1 and BRCA2 genes Age
Prostate cancer	Obesity Bad food habits Low intake of fiber	Age Race
Colorectal cancer	Unhealthy diet Insufficient physical activity	Age Race Family history Diabetes

Chronic respiratory diseases Some of the most under-diagnosed conditions, chronic respiratory diseases (CRD) are a potent cause of death globally with 90% of the deaths taking place in low-income countries. Chronic obstructive pulmonary disease (COPD) and asthma are the two main types of CRDs.

Modifiable Risk Factors	Non-Modifiable Risk Factors
Cigarette smoke Dust and chemicals Environmental tobacco smoke Air pollution Infections	Genetics Age

CVD – A global epidemic As stated earlier, CVD is the number one cause for deaths globally and the number of people dying from it each year is constantly rising. It is estimated that by 2030, CVD will be responsible for more deaths in low income countries than infectious diseases, maternal and perinatal conditions, and nutritional disorders combined.9 Figure 2 highlights the prominence of CVD in global mortality trends in comparison to other causes.

CVDs are the face of lifestyle diseases and manifest in a number of ways, such as: Coronary heart disease (CHD): Also known as coronary heart disease and ischaemic heart disease, CHD is one of the most common types of heart problems faced today and is characterised by a reduction or blockage in the flow of oxygen-rich blood to the heart muscle.

This puts exaggerated strain on the heart, which can lead to:

Angina – chest pain caused by lack of flow of blood to the heart Heart attacks – caused when the blood flow to the heart is suddenly but completely blocked Heart failure – the failure of the heart to pump blood properly to the rest of the body

C erebrovascular disease (strokes and TIAs) : Cerebrovascular disease is the disease of blood vessels supplying blood to the brain. When the blood supply to the brain is cut off, a person suffers a stroke, which can be lethal. A transient ischaemic attack, popularly known as a mini-stroke, occurs when the blood supply to the brain is temporarily blocked.

F ace: Face drooping on one side is the most common visible symptom, followed by dropping of mouth or eye. A rms: Weakness of numbness in one or both arms doesn’t allow a person to raise both of his or her hands up and hold them there. S peech: Slurred or garbled speech in some cases, and in other cases: no speech. T ime: It is time to call the emergency services if you see any of these symptoms.

Other symptoms include:

Blurred or complete loss of vision in one or both eyes One-sided weakness or numbness of the body Sudden memory loss or confusion Sudden dizziness combined with any of the above mentioned symptoms can be a definite sign

Peripheral arterial disease : Peripheral arterial diseases is a disease of blood vessels supplying the arms and legs. It happens when there is a blockage in the arteries to the limbs (usually the legs). Signs to watch out for:

Dull or cramping pain that gets worse with walking and better with rest Hair loss on the limbs Numbness or weakness in the limbs Persistent ulcers on the legs and feet

Rheumatic heart disease : Rheumatic heart disease is characterised by damage to the heart muscle and heart valves from rheumatic fever, caused by streptococcal bacteria. Some of the most common symptoms are fever and painful, tender joints. Congenital heart disease : Congenital heart disease is a problem with the structure of the heart, i.e.

1. Malformations of heart structure, that exist at birth.
2. The problem can range from a small hole in the heart to a more severe problem such as a defective heart muscle.
3. Some of the common symptoms are shortness of breath and having trouble exercising.
4. In infants and younger kids, cyanosis, a bluish tint to the skin, fingernails and lips can be an important marker.

Risk factors include:

Use of certain medications, drugs or alcohol during pregnancy Viral infections in the mother in the first trimester Genetic problems or issues with chromosomes of the child

Pulmonary embolism due to deep vein thrombosis (DVT): DVTs are blood clots, often found in the veins of the legs, which can dislodge and move to the heart and lungs, causing pulmonary embolism. This condition can be life-threatening and special care should be taken if diagnosed with DVT. Symptoms include:

Chest pain – may get worse with deep breaths Sudden shortness of breath Sudden cough or coughing up blood Anxiety Light-headedness and fainting

Aortic disease: Aortic diseases are a group of conditions that affect the aorta, the largest blood vessel in the body. The aorta is responsible for carrying blood from the heart to the rest of the body. An example of an aortic disease would be aortic aneurism, where the walls of the aorta are weakened, leading to outward bulging of the blood vessel.

1. Usually symptomless, this condition can lead to life-threatening circumstances if it bursts.
2. Managing CVD: Depending on the type of CVD, an appropriate treatment plan can help alleviate the problem/s.
3. There are a number of treatments ranging from medication to surgeries that can help, however, prevention is always recommended over treatment.

To prevent CVD, one must:

Stop smoking Have a balanced diet with plenty of fibre Exercise regularly (>150 minutes of aerobic activity per week) Maintain a healthy weight and body mass index (BMI; aim for a BMI below 25) Cut down on alcohol (<14 alcohol units per week) Aspirin and anti-platelet therapy 11

Control and prevention of lifestyle diseases An important way of controlling non-communicable diseases is by controlling the risk factors associated with it. In other words, a number of communicable diseases can be prevented by controlling the behavioural or lifestyle habits associated with those diseases.

There are a number of low-cost solutions that can be implemented by the government and other involved groups to reduce the common modifiable risk factors.1 Monitoring the trends of non -communicable diseases and their associated risks is crucial for guiding policies and guidelines. A comprehensive approach is essential that involves all sectors including health, finance, education, planning and others, to minimise the impact of lifestyle diseases on individuals and society.

The approach needs to instigate a collaborative effort to minimise the risks associated with no communicable diseases and at the same time inspire interventions to control and prevent them. Lifestyle diseases are a threat to the socio-economic aspects of nations globally and appropriate actions for their management are the need of the moment.

Management of lifestyle diseases includes proper diagnosis, screening and treatment of these diseases in addition to providing palliative care for people who require it. Quality lifestyle disease intervention needs to be delivered through a primary healthcare approach where early detection and proper treatment are prioritised.4 7 Mathers CD, Loncar D (2006).

Projections of Global Mortality and Burden of Disease from 2002 to 2030.PLoS Medicine, 3(11), e442.8 WHO (2017) Cancer. Fact Sheet. (Retrieved from: http://www.who.int/mediacentre/factsheets/fs297/en/ on 1/05/2017) 9 Beaglehole R, Bonita R. (2008). Global public health: A scorecard.

1. Lancet, 372(9654):1988–1996.10 NHS (2017).
2. Act F.A.S.T.
3. If you think someone is having a stroke.
4. NHS information leaflet.
5. Retrieved from: http://www.nhs.uk/actfast/Documents/ActFAST_Leaflet2017_EasyRead.pdf on 1/05/2017) 11 Wong ND (2015) Epidemiology and prevention of cardiovascular disease.
6. In Detels, R., Gulliford, M, et al.

Oxford Textbook of Global Public Health (6 ed.). Oxford University Press. ©2017 Tabish. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.

What are the 8 killer diseases?

Eight Most Deadly Infectious Diseases 1990 vs.2004

Tuberculosis	Bacterium	9 million
Malaria	Sporozoan	110 million
AIDS	HIV	5.6 million
Measles	Virus	200 million
Hepatitus B	Virus	200 million

What is the biggest killer of children?

Firearms recently became the number one cause of death for children in the United States, surpassing motor vehicle deaths and those caused by other injuries. We examine how gun violence and other types of firearm deaths among children and teens in the United States compares to rates in similarly large and wealthy countries.

1. We select comparable large and wealthy countries by identifying Organization for Economic Co-operation and Development (OECD) member nations with above median GDP and above median GDP per capita in at least one year from 2010-2020.
2. Using the Centers for Disease Control and Prevention (CDC) Wonder database and the Institute for Health Metrics and Evaluation (IHME) Global Burden of Disease (GBD) study data, we compare fatality rates and disability estimates for people ages 1 through 19.

(Since estimates were not available for children ages 1-17 alone, young adults ages 18 and 19 are grouped with children for the purposes of this brief). We find that the United States is alone among peer nations in the number of child firearm deaths. In no other similarly large or wealthy country are firearm deaths in the top 4 causes of mortality let alone the number 1 cause of death among children.

In 2020 (the most recent year with available data from the CDC), firearms were the number one cause of death for children ages 1-19 in the United States, taking the lives of 4,357 children. With the exception of Canada, in no other peer country were firearms among the top five leading causes of childhood deaths.

Motor vehicle accidents and cancer are the two most common causes of death for this age group in all other comparable countries. Combining all child firearm deaths in the U.S. with those in other OECD countries with above median GDP and GDP per capita, the U.S.

1. Accounts for 97% of gun-related child deaths, despite representing 46% of the total population in these similarly large and wealthy countries.
2. Combined, the eleven other peer countries account for only 153 of the total 4,510 firearm deaths for children ages 1-19 years in these nations in 2020, and the U.S.

accounts for the remainder. Firearms account for 20% of all child deaths in the U.S., compared to an average of less than 2% of child deaths in similarly large and wealthy nations. On a per capita basis, the firearm death rate among children in the U.S.

• Is about 7 times the rate of Canada, the country with the second-highest child firearm death rate among similarly large and wealthy nations.
• If firearm deaths in the U.S.
• Occurred at rates seen in Canada, we estimate that approximately 26,000 fewer children’s lives in the U.S.
• Would have been lost since 2010 (an average of about 2,300 lives per year).

This would have reduced the total number of child deaths from all causes in the U.S. by 12%. After reaching a recent low (of 3.1 firearm deaths per 100,000 children) in 2013, the U.S. saw an 81% increase (to 5.6 firearm deaths per 100,000 children) by 2020, just seven years later.

The U.S. is the only country among its peers that has seen an increase in the rate of child firearm deaths in the last two decades (42% since 2000). All comparably large and wealthy countries have seen child firearm deaths fall since 2000. These peer nations had an average child firearm death rate of 0.7 per 100,000 children in the year 2000, falling 56% to 0.3 per 100,000 children in 2019.

Not all firearm deaths are a result of violent attacks. In the U.S., in 2020, 30% of child deaths by firearm were ruled suicides, and 5% were unintentional or undetermined accidents. However, the most common type of child firearm death is due to violent assault (65% of all child firearm deaths are assault).

• The spike in 2020 child firearm deaths in the U.S.
• Was primarily driven by an increase in gun assault deaths.
• The child firearm assault mortality rate reached a high in 2020 with a rate of 3.6 per 100,000, a 39% increase from the year before.
• The firearm suicide mortality rate among children in the U.S.

increased 13% from 2019 to 2020, 31% since 2000, and 89% since the recent low in 2010. Not only does the U.S. have by far the highest overall firearm death rate among children, the U.S. also has the highest rates of each type of child firearm deaths — suicides, assaults, and accident or undetermined intent — among similarly large and wealthy countries.

The U.S. also has a higher overall suicide rate (regardless of whether a firearm is involved) among peer nations. In the U.S., the overall child suicide rate is 3.6 per 100,000 children, and 1.7 per 100,000 children died by suicide from firearms. In comparable countries, on average, the overall child suicide rate is 2.8 per 100,000 children, and 0.2 per 100,000 children died by suicide from firearms.

If the U.S. child firearm suicide rate was brought down to 0.2 per 100,000 children (the same as the average in peer countries), 1,100 fewer children would have died in 2020 alone. Exposure and use of firearms also has implications for children’s mental health.

Methods

Data from CDC Wonder 2020 Underlying Cause of Death database and IHME Global Burden of Disease (GBD) 2019 study were used. Underlying cause of death categories are from IHME – GBD Level 3 Causes of Death. Top 20 leading causes of death among children ages 1-19 were ranked for the U.S. and comparable countries. These top 20 causes of death include: firearms, motor vehicle traffic, other injuries, congenital diseases, cancer, substance use disorders, cardiovascular diseases, infectious diseases, chronic respiratory diseases, respiratory infections, neurological disorders, diabetes and kidney diseases, maternal and neonatal complications, digestive diseases, nutritional deficiencies, HIV/AIDS and STIs, musculoskeletal disorders, skin and subcutaneous diseases, other mental disorders, and neglected tropical diseases. Unintentional firearm deaths include undetermined intent firearm deaths. Motor vehicle deaths include motor vehicle, pedestrian, other transport, being struck by or against a vehicle in traffic, and other land transport deaths. Other injuries encompass all injuries that are not from firearms, motor vehicles, or poisonings from substance use disorders, but not from injuries incurred via medical care. Cancer includes both malignant and in situ neoplasms. Congenital diseases include congenital malformations, deformations, and chromosomal disorders, as well as any disease/disorder that could not be identified via laboratory tests or examinations. Other mental disorders (not shown in the tables above but accounted for in analyses) include all deaths from mental health disorders, excluding suicide via firearm or other injury or poisonings via substance use disorder.

What disease has a 100 mortality rate?

Rabies – Rabies, one of the oldest known infectious diseases, is nearly 100% fatal and continues to cause tens of thousands of human deaths globally ( 1 ). Canine rabies has been eliminated in North America and many South American and European countries, but it is still the source of most human rabies cases in other areas, primarily in many African and Asian countries ( 2, 3 ).

Urbanization and lack of aggressive rabies elimination programs may have contributed to resurgence of canine rabies–associated human deaths in several provinces in China ( 4, 5 ). In the United States, the number of human deaths from rabies has declined to an average of 3 cases per year during the last several decades ( 1 ).

Apart from a few imported canine rabies cases, most human cases in the United States resulted primarily from bat rabies virus variants. Nonetheless, suspected or confirmed human exposures in the United States result in tens of thousands of postexposure prophylaxis regimens every year ( 6 ).

What disease do they call the silent killer?

DIABETES – Have you seen your doctor lately? Do you have a primary care physician? High blood pressure and diabetes are known as “silent killers” because a lot of the time people have these conditions, but, if they are not seen by their doctor for regular checkups, they do not know that they have them.

That is, these conditions normally do not cause any symptoms until they are well-advanced and have caused irreversible damage to your internal organs. Your doctor can check you for these conditions. If treated early enough, you may be able to prevent permanent damage to your internal organs. If you have any of these conditions, and do not get treatment, you can cause permanent damage to your kidneys and to your heart.

You may end up having a sudden heart attack, stroke, or coma. If you survive long enough, your kidneys may stop working and you may then need to go on dialysis. A little prevention can prevent a lot of medical problems years from now. Some premature deaths due to these conditions are preventable,

What is the first largest killer disease?

1 killer: Heart disease.