Antispasmodics: Centrally Acting Skeletal Muscle Relaxers
- Carisoprodol (Soma) Carisoprodol is a centrally acting muscle relaxant.
- Chlorzoxazone (Lorzone, Parafon Forte DSC, Remular-S)
- Cyclobenzaprine (Amrix)
- Metaxalone (Skelaxin)
- Methocarbamol (Robaxin)
- Orphenadrine (Norflex)
- Baclofen (Ozobax)
- Tizanidine (Zaniflex)
- 1 What vitamins are good for muscle repair?
- 2 What is the longest acting muscle relaxant?
- 3 Does B12 help muscles?
Which medicine is best for muscle pain?
Managing Sore Muscles and Aches and Pains You work hard all week, so when the weekend finally rolls around, you want to play just as hard. There’s nothing like a few rounds of golf, a hike in the mountains, or an intense workout at the gym to help you feel recharged. But all of that exercise can cause soreness and stiffness that shows up a day or two later.
You did something you’re not used to, like running a marathon when you normally jog just a few miles.You suddenly kicked up your exercise intensity level or increased the length of your workout.You did unusual exercises that lengthen instead of shorten your muscle, like walking downhill or extending your arm during a bicep curl.
These changes to your exercise routine can lead to tiny injuries in your muscle fibers and connective tissue. About a day later, you’ll start to feel sore. “We call that ‘delayed onset’ muscle soreness,” says Ethel Frese, PT, associate professor of physical therapy at St.
Louis University. “It peaks within about 48 hours, and then it will gradually get better.” The good news is that when you do the same activity again, your muscles will start to get used to it. “You will actually have no soreness or less soreness because now you’ve strengthened the muscle or connective tissue,” says Allan H.
Goldfarb, PhD. He’s a professor and exercise physiologist at the University of North Carolina, Greensboro. When your joints feel sore and achy, that’s usually a sign of osteoarthritis. This inflammatory condition becomes more common as you get older. The cartilage that normally cushions the joints wears away, leaving the joints inflamed and painful.
- Joint pain can also be caused by overuse or injury, for example, tennis elbow or a knee injury caused by problem with a ligament or meniscus.
- Ligaments are bands of tissue that connect bones in your body.
- A meniscus is a rubbery disc that cushions your knee.
- One big question a lot of people have when they’re nursing sore muscles is whether to use heat or ice.
Experts say indirect ice – an ice pack wrapped in a thin towel – is best for immediate relief. “Heat will feel good while it’s on, but it’s not going to lessen the damage or make it go away anytime soon,” Frese says. Goldfarb suggests you ice the sore area right after the activity to cut inflammation.
- Then use heat later to increase blood flow to the area.
- Heat also can help relieve joint pain.
- If you get sore muscles once in a while, you can take acetaminophen or a nonsteroidal anti-inflammatory drug (NSAID) like aspirin, ibuprofen, or naproxen to help ease the discomfort.
- Just be cautious about using NSAIDs regularly.
Long-term use can interfere with your muscle’s ability to repair itself, Goldfarb says. Check with your doctor or pharmacist about any interactions these over-the-counter drugs may have with other medications you take. Also, you may need to avoid some medications if you have ulcers, kidney disease, liver disease, or other conditions.
- Sometimes soothing sore muscles requires more than an ice pack or over-the-counter pain reliever.
- Muscle pain that comes on quickly and feels intense is a sign that you’ve injured yourself.
- Call your doctor if your pain is severe or lasts for more than a few days.
- Experts used to recommend stretching before a workout to prevent sore muscles.
But research shows that stretching ahead of time doesn’t do much to prevent soreness or injury. Frese says it’s better to get in a good warm-up before you exercise. Stretch later, when your muscles are already warm. A couple of natural substances are touted for preventing sore muscles, including antioxidants like vitamin C.
But check with your doctor before taking high doses of any vitamin. Serious exercisers might find relief from post-workout soreness by taking in some protein. A study of marines found that protein supplements helped sore muscles after intense exercise. One of the best ways to prevent sore muscles is by easing your way into your exercise routine.
“Start off with lighter exercise and gradually build up,” Frese says. If you have a medical condition or you’re unsure about your health, check with your doctor before starting an exercise program. They can help you find an exercise routine that’s safe and effective for you.
- When you have joint pain, you may be tempted to curl up in bed.
- One of the best things you can do for your joints, though, is to exercise.
- Our joints need to move to get nutrition,” Frese says.
- Weight-bearing exercises can help strengthen the muscles that support the joint.
- Just watch that you don’t exercise to the point of pain.
It also can help to work with a physical therapist, who can show you how to exercise safely and how to keep good posture so that you don’t get injured or worsen joint pain. © 2010 WebMD, LLC. All rights reserved. SOURCES: Ethel Frese, PT, DPT, CCS, associate professor of physical therapy, St.
- Louis University. Allan H.
- Goldfarb, PhD, FACSM, professor, exercise physiologist, University of North Carolina, Greensboro.
- Anderson, J.
- Journal of Athletic Training, July-September 2005.
- Connolly, D.
- Journal of Sports Medicine and Physical Fitness, September 2006.
- Flakoll, P.
- Journal of Applied Physiology, March 2004.
Herbert, R. and de Noronha, M. Cochrane Database Systematic Reviews, 2007. : Managing Sore Muscles and Aches and Pains
Which tablet is best for muscle relaxant?
Taken as 800 mg tablets 3 to 4 times a day, metaxalone (Skelaxin) has the fewest reported side effects and lowest sedation potential of the muscle relaxants based on clinical studies. Simply put, it is the best-tolerated of the muscle relaxants.
What vitamins are good for muscle repair?
Vitamin B12 – A key ingredient in the Advance Multivitamin, vitamin B12 plays an important role in the body’s production of red blood cells, which are the cells that deliver oxygen to the muscles. Additionally, one 2016 study found that the rebuilding and repairing of muscles requires vitamin B12 as as cofactor, alongside folate.
What causes muscle pain?
The most common causes of muscle pain are tension, stress, overuse and minor injuries. This type of pain is usually localized, affecting just a few muscles or a small part of your body.
What is a very strong muscle relaxer?
They include cyclobenzaprine (Flexeril), methocarbamol (Robaxin), and tizanidine (Zanaflex), among others. According to the American Academy of Family Physicians, there is no clear evidence that one is better or stronger than another.
What is the longest acting muscle relaxant?
Abstract – Four new nondepolarising muscle relaxants, pipecuronium bromide, doxacurium chloride, mivacurium chloride and Org 9426 (rocuronium) offer alternatives to the established agents atracurium besilate and vecuronium bromide. Pipecuronium and Org 9426 are steroidal compounds, the latter being a monoquaternary agent, whereas doxacurium and mivacurium are bisquaternary benzylisoquinolinium compounds.
Pipecuronium and doxacurium have a relatively slow onset and a long duration of action. Pipecuronium produces maximum block in 3 to 6 min when given in a dose of 45 to 80 micrograms/kg, and a duration of clinical relaxation of between 40 and 110 min. Doxacurium is more potent, but is the least rapid and the longest acting relaxant currently available.
When administered in doses of 37 to 80 micrograms/kg, it produces maximum block within 3.5 to 10 min, with a duration of clinical relaxation of 77 to 164 min. The advantage of both pipecuronium and doxacurium is their cardiovascular stability. Both agents are primarily eliminated via the kidneys and both have now been licensed for use in the US.
- Mivacurium is a muscle relaxant with a short duration of action.
- When administered in doses of 0.1 to 0.25 mg/kg it produces maximum block in 2 to 4 min, but the duration of clinical relaxation is less than 20 min.
- Higher doses which could induce a faster neuromuscular block are unfortunately associated with some histamine liberation.
The drug is metabolised by plasma cholinesterase. Mivacurium has also been licensed for use in the US. Org 9426 is an agent with a rapid onset but an intermediate duration of action. A dose of 0.5 to 0.6 mg/kg induces maximum block in about 1.5 min and has a duration of clinical relaxation of about 30 min.
What drugs relax muscles and nerves?
Common Muscle Relaxants – Muscle relaxers are usually prescribed to treat back pain in conjunction with rest and physical therapy. Common muscle relaxants include:
Baclofen, Muscle tightness and muscle spasms, including those related to spine injuries, may be eased with baclofen. The medication may be helpful in treating multiple sclerosis and stabbing nerve pain. It is available as a tablet and can be taken by children as young as 12 years old. Some common side effects could include nausea and vomiting, confusion, drowsiness, headache, or muscle weakness. Baclofen is rated C in the FDA’s A through X pregnancy safety ranking for medications, with A being the safest. The C category means that the medication should only be used if the benefits outweigh the risks. Benzodiazepines, In addition to treating anxiety, alcohol withdrawal, and seizure disorders, such as epilepsy, benzodiazepines can also treat muscle spasms and skeletal pain. Benzodiazepines, such as diazepam (Valium), lorazepam (Ativan), and temazepam (Restoril), are typically only intended for short-term use. This limitation is due to their habit-forming potential and because they alter sleep cycles, leading to sleep difficulties once the drug is stopped. Benzodiazepines are sold as tablets, liquid, injections, and rectal gels. People who have myasthenia gravis, severe liver disease, serious breathing troubles, or some forms of glaucoma, should avoid taking diazepam. All benzodiazepines are rated D by the FDA for safety during pregnancy and are not recommended for women who are pregnant.
Are muscle relaxers better than pain pills?
What are the best prescription muscle relaxers? – There are certain times when over-the-counter medications simply aren’t enough. If you’ve been taking acetaminophen or ibuprofen consistently but still dealing with back pain, spasms, or other issues, it might be time for something more robust.
- In cases like these, doctors may look to prescription muscle relaxants as a more effective, albeit temporary, answer.
- When approached about more serious conditions or injuries, Dr.
- Lewis doesn’t often recommend OTC remedies.
- A pulled back muscle or neck pain may require a doctor’s visit or other diagnostic tests to get to the heart of the issue,” she said.
“There are several good prescription medications like methocarbamol, cyclobenzaprine, and metaxalone.” Recent studies have shown that a type of skeletal muscle relaxants (SMRs), called antispasmodics, outperform anti-inflammatory drugs (NSAIDs), like ibuprofen and acetaminophen, in relieving severe pain associated with conditions like acute back pain,
What is the brand name for muscle relaxers?
List of centrally acting SMRs
|Generic name||Brand name||Form|
|cyclobenzaprine||Fexmid, Flexeril, Amrix||tablet, extended-release capsule|
Does B12 help muscles?
The Role of Bodybuilding Vitamins – Bodybuilders and other athletes spend hours in the gym training, and those who compete follow strict diets to get leaner and more defined. It’s important not to go too low on the caloric intake, since it can actually prevent you from building muscle.
Sports nutrition can help in these areas, allowing you to get high amounts of protein, which boosts lean muscle mass and supports weight loss. In fact, a study published in the American Journal of Physiology, Endocrinology and Metabolism found bodybuilders taking 20 grams of protein (in this case, whey) before or after they hit the gym boosted their amino acid levels, which is necessary for putting on muscle.
That’s not all, though: Vitamins and minerals should be part of your muscle building regimen as well. Deficiencies can impact your body is several ways, which isn’t helpful when it comes to getting the gains you need. In short, protein alone isn’t enough! Many vitamins fight inflammation, support stress levels, and promote immune health.
They can also help support hypertrophy — otherwise known as muscle size increase. All of this is crucial in your journey toward muscle growth and repair. Over-supplementation and inappropriate use of supplements can be dangerous, so be sure to consult with your healthcare provider or a BodyLogicMD-affiliated practitioner prior to implementing a supplement regimen.
But now, let’s take a quick look at the ABCs of vitamins that promote muscle growth and repair:
Vitamin D has been given the nickname of “the sunshine vitamin,” and that’s because we get it from sunlight. However, it’s hard to get the amount you need when you work indoors or don’t live in a sunny state. The vitamin helps you maintain healthy bones and support protein synthesis, which what we need to stay healthy and strong.
- Vitamin D also helps promote nutrient absorption, mood balance, and insulin.
- And when we’re older, it can especially affect us.
- You can get vitamin D supplements here.
- Although it can be difficult to get enough vitamin D from diet alone, eating plenty of fatty fish (think tuna, mackerel, and salmon), soy milk, beef liver, egg yolk, and cheese help keep levels of this important vitamin high.
You may want to take vitamin D3 with vitamin K2, which is an important pairing. According to Healthline, vitamin D allows you to absorb calcium, which vitamin K then directs appropriately to build bone. Without vitamin K, calcium can build up in your arteries instead of your bones and contribute to heart disease.
Vitamin B12 helps your body produce red blood cells, which are responsible for delivering oxygen to the muscles. This action makes B12 a key player in muscle growth. You can find this one in most of the foods you eat, like fish, dairy and poultry. A word of warning: vegans and vegetarians are at higher risk of deficiency, so be sure to eat plant milks, soy and soya beans, and some fortified cereals.
Vitamin B3 (also called Niacin) supports muscle growth and gives you better pumps. That’s why so many bodybuilders and fitness models load up on this nutrient before photo shoots. It also can promote the metabolism of glucose, increase good cholesterol (while limiting your bad cholesterol) and support healthy hormone production.
Noticing a trend here? The B vitamin family are power players when it comes to bodybuilding and muscle repair. You’ll want to get enough of this vitamins, as it can promote red blood cell production and healthy levels of nitric oxide (which is produced naturally in the body and can support performance and endurance).
To get this into your diet, you’ll want to add fish (especially fatty fish, like albacore tuna and salmon), chickpeas, and bananas. If you’re not into beef liver or fatty fish, or if you don’t eat meat, chickpeas and bananas are your friend: One can of chickpeas, for instance, delivers over 55 percent of the daily recommended amount of B6.
Think about supplementing with a B6 vitamin as well.
Vitamin E is well-known for its skin-loving properties, but it isn’t just for your skin. Vitamin E not only slows down aging and scavenges free radicals (substances from the environment or toxins that are harmful to our health and can cause chronic illness), but also helps flush out metabolic waste.
This vitamin is unparalleled, as it supports protein synthesis and the creation of glycogen. It also helps our eyes, fights free radicals, and supports healthy, strong bones. The problem with vitamin A, however, is that it can be made deficient by lots of environmental factors — alcohol, illness (like diabetes) and low fat diets.
This is likely the one vitamin you know all about; most of us have been taking it at our mother’s request since childhood! Most people use vitamin C when it comes to boosting their immune function and upping their antioxidant levels. This vitamin can even help repair damaged tissues, which is a big deal when you’re hitting the gym.
Omega-3 Fatty Acids
According to recent human studies, omega-3 fatty acids (like those from fish) “can influence the exercise and nutritional response of skeletal muscle” and reduce post-exercise muscle soreness. Omega-3s have been found to speed up recovery and boost muscle growth on top of providing support to our cardiovascular, eyes, joint, brain, and skin health.
This ones also supports energy production, so it is key for anyone trying to make big gains at the gym. Additionally, this supplement can also work wonders after you lift — by reducing the soreness after a good workout. This helps to get you back into the gym sooner, rather than waiting a long time for muscle recovery.
Vitamin B9 (Folate or Folic Acid)
Vitamin B9 is key for muscle growth. Here’s what you should know: Folic acid is the synthetic (artificial; produced by chemical biosynthesis) version of vitamin B9. Folate, however, is vitamin B9 that occurs naturally in food, according to BreakingMuscle,
Does B12 help muscle soreness?
2. B Vitamins – B-complex vitamins give us the energy to repair, heal, and keep on moving. Studies show that B vitamins help to metabolize the protein we need to make new muscle cells, as well as repair those micro-tears that cause soreness. Certain B vitamins offer different benefits.
- For instance, B12 is essential for producing healthy blood cells to oxygenate your muscles, whereas B6 improves performance and endurance.
- For the best results, choose a complete B-complex to reap the comprehensive benefits of all the B vitamins.
- What to Eat: A banana,
- Bananas are the perfect post-workout snack.
They reduce in flammation, aid in muscle recovery and growth, and pack in those essential B vitamins (plus they’re a healthy way to attend to a sweet tooth).
What tablets are good for bones and joints?
Learn which supplements and vitamins might help with arthritis symptoms, and what risks some can pose. Several nutritional supplements have shown promise for relieving pain, stiffness and other arthritis symptoms. Glucosamine and chondroitin, omega-3 fatty acids, SAM-e and curcumin are just some of the natural products researchers have studied for osteoarthritis (OA) and rheumatoid arthritis (RA).
- Some of these natural remedies may offer arthritis symptom relief, especially when you use them in conjunction with traditional treatments.
- Here’s the evidence on some of the most popular supplements used to treat arthritis, and how they work.
- Glucosamine and Chondroitin Glucosamine and chondroitin are two of the most commonly used supplements for arthritis.
They’re components of cartilage—the substance that cushions the joints. Research on these supplements has been mixed, in part because studies have used varying designs and supplement types. A large National Institutes of Health study called the GAIT trial compared glucosamine and chondroitin, alone or together, with an NSAID and inactive treatment (placebo) in people with knee osteoarthritis (OA).
- Glucosamine improved symptoms like pain and function, but not much better than a placebo.
- Yet a 2016 international trial found the combination to be as effective as the NSAID celecoxib at reducing pain, stiffness and swelling in knee OA.
- Studies have also differed on which form of the supplements is most effective.
Some evidence suggests glucosamine sulfate is best. Others find glucosamine hydrochloride to be more effective. One study that compared the two forms head to head showed they offered equivalent pain relief. Mayo Clinic researchers say evidence supports trying glucosamine sulfate – not hydrochloride – with or without chondroitin sulfate for knee OA.
- Fish oil The polyunsaturated omega-3 fatty acids found in fish have potent anti-inflammatory properties.
- Omega-3 fats seem to work better for rheumatoid arthritis than for osteoarthritis, most likely because rheumatoid arthritis is mainly driven by inflammation,” says Chris D’Adamo, PhD, director of Research & Education at the University of Maryland School of Medicine Center for Integrative Medicine.
A 2017 systematic review of studies found that omega-3 supplements reduced joint pain, stiffness and swelling in RA. Taking these supplements might help some people cut down on their use of pain relievers – and avoid their side effects. “For mild cases of arthritis, it may be better to reach for the supplements before you go for the ibuprofen,” says Farshad Fani Marvasti, MD, MPH, director of Public Health, Prevention, and Health Promotion at The University of Arizona.
- Omega-3s have the added benefit of protecting against heart disease and dementia, he says.
- Plant-based sources such as flax and chia seeds also contain omega-3s, but in the form of short-chain alpha-linolenic acid (ALA).
- It’s the long-chain omega-3 fatty acids – eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) – that have the majority of the health benefits,” D’Adamo says.
When you buy fish oil, make sure the supplement lists the EPA and DHA content, and that you take at least one gram each of EPA and DHA, he adds. Vegans can get these omega-3s from an algae-based supplement. SAM-e S-adenosyl-methionine (SAM-e) is a natural compound in the body that has anti-inflammatory, cartilage-protecting and pain-relieving effects.
- In studies, it was about as good at relieving OA pain as NSAIDs like ibuprofen and celecoxib, without their side effects.
- SAM-e has a bonus benefit, too.
- The supplement is most useful when you also have depression, because it has a mild to moderate antidepressant effect,” Marvasti says.
- The typical SAM-e dose is 1,200 mg daily.
If you plan to try this supplement, be patient. “It’s going to take a few weeks to see the full effects,” D’Adamo says. Curcumin Curcumin is the active compound in the yellow-hued spice, turmeric, which is a staple of Indian curries. In the body, it acts as a powerful anti-inflammatory agent, blocking the same inflammation-promoting enzyme as the COX-2 inhibitor drug, celecoxib.
- In a study of 367 people with knee OA, a 1,500 mg daily dose of curcumin extract was as effective as 1,200 mg a day of ibuprofen, without the gastrointestinal side effects.
- This supplement also appears to relieve RA swelling and tenderness.
- One downside to curcumin is that it’s hard for the body to absorb.
“You want to take it with a source of fat. Some of the supplements will be in an oil base, which is really important,” D’Adamo says. Black pepper also increases the absorption. Some supplements add the black pepper extract, piperine. However, piperine could potentially cause liver damage, and it can increase the absorption of medications like carbamazepine (Tegretol) and phenytoin (Dilantin), making them more potent.
- Vitamins Several vitamins have been studied for their effects on arthritis, including the antioxidant vitamins A, C, and E, and vitamins D and K.
- So far there’s no evidence that taking antioxidant vitamins improves arthritis symptoms, although eating a diet rich in these nutrients is healthy overall.
Vitamins D and K are both important for bone strength, and vitamin K is involved in cartilage structure. Supplementing these two nutrients may be helpful if you’re deficient in them. Supplement Risks When you take supplements as directed and under your doctor’s supervision, they’re generally safe.
- Yet even though they’re labeled “natural,” supplements can sometimes cause side effects or interact with the medicines you take.
- For example, high-dose fish oil supplements can thin the blood and may interact with anticoagulant medicines such as warfarin (Coumadin).
- Sometimes you can overdo it and take too much, especially when it comes to vitamins.
Some vitamins – like B and C – are water soluble. That means if you take too much of them, your body will flush out the extra. Yet fat-soluble vitamins such as A, D, E and K can build up in your body to the point where they become harmful, so check with your doctor about safe amounts.
Finally, supplements don’t go through the same rigorous approval process from the Food and Drug Administration (FDA) as medicines. The FDA has to review and approve every medication to make sure it works and that it’s safe. With supplements, the ingredients listed on the label may not be the same ones that are in the bottle.
How to Take Supplements Safely If you do want to try supplements, use them as an add-on to arthritis drugs, not as a replacement. They should never take the place of medications, which are the only proven way to slow joint damage. Always check with your doctor before you try any new supplement to make sure that it’s right for you, and that you’re taking a safe dose.