What Is The Deadliest Disease In Human History?

– The deadliest disease in the world is coronary artery disease (CAD). Also called ischemic heart disease, CAD occurs when the blood vessels that supply blood to the heart become narrowed. Untreated CAD can lead to chest pain, heart failure, and arrhythmias.


What is the deadliest disease known to man?

– The deadliest disease in the world is coronary artery disease (CAD). Also called ischemic heart disease, CAD occurs when the blood vessels that supply blood to the heart become narrowed. Untreated CAD can lead to chest pain, heart failure, and arrhythmias.

What is the number one killer of children?

Firearms recently became the number one cause of death for children in the United States, surpassing motor vehicle deaths and those caused by other injuries. We examine how gun violence and other types of firearm deaths among children and teens in the United States compares to rates in similarly large and wealthy countries.

  • We select comparable large and wealthy countries by identifying Organization for Economic Co-operation and Development (OECD) member nations with above median GDP and above median GDP per capita in at least one year from 2010-2020.
  • Using the Centers for Disease Control and Prevention (CDC) Wonder database and the Institute for Health Metrics and Evaluation (IHME) Global Burden of Disease (GBD) study data, we compare fatality rates and disability estimates for people ages 1 through 19.

(Since estimates were not available for children ages 1-17 alone, young adults ages 18 and 19 are grouped with children for the purposes of this brief). We find that the United States is alone among peer nations in the number of child firearm deaths. In no other similarly large or wealthy country are firearm deaths in the top 4 causes of mortality let alone the number 1 cause of death among children.

In 2020 (the most recent year with available data from the CDC), firearms were the number one cause of death for children ages 1-19 in the United States, taking the lives of 4,357 children. With the exception of Canada, in no other peer country were firearms among the top five leading causes of childhood deaths.

Motor vehicle accidents and cancer are the two most common causes of death for this age group in all other comparable countries. Combining all child firearm deaths in the U.S. with those in other OECD countries with above median GDP and GDP per capita, the U.S.

  • Accounts for 97% of gun-related child deaths, despite representing 46% of the total population in these similarly large and wealthy countries.
  • Combined, the eleven other peer countries account for only 153 of the total 4,510 firearm deaths for children ages 1-19 years in these nations in 2020, and the U.S.

accounts for the remainder. Firearms account for 20% of all child deaths in the U.S., compared to an average of less than 2% of child deaths in similarly large and wealthy nations. On a per capita basis, the firearm death rate among children in the U.S.

is about 7 times the rate of Canada, the country with the second-highest child firearm death rate among similarly large and wealthy nations. If firearm deaths in the U.S. occurred at rates seen in Canada, we estimate that approximately 26,000 fewer children’s lives in the U.S. would have been lost since 2010 (an average of about 2,300 lives per year).

This would have reduced the total number of child deaths from all causes in the U.S. by 12%. After reaching a recent low (of 3.1 firearm deaths per 100,000 children) in 2013, the U.S. saw an 81% increase (to 5.6 firearm deaths per 100,000 children) by 2020, just seven years later.

  1. The U.S. is the only country among its peers that has seen an increase in the rate of child firearm deaths in the last two decades (42% since 2000).
  2. All comparably large and wealthy countries have seen child firearm deaths fall since 2000.
  3. These peer nations had an average child firearm death rate of 0.7 per 100,000 children in the year 2000, falling 56% to 0.3 per 100,000 children in 2019.
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Not all firearm deaths are a result of violent attacks. In the U.S., in 2020, 30% of child deaths by firearm were ruled suicides, and 5% were unintentional or undetermined accidents. However, the most common type of child firearm death is due to violent assault (65% of all child firearm deaths are assault).

The spike in 2020 child firearm deaths in the U.S. was primarily driven by an increase in gun assault deaths. The child firearm assault mortality rate reached a high in 2020 with a rate of 3.6 per 100,000, a 39% increase from the year before. The firearm suicide mortality rate among children in the U.S.

increased 13% from 2019 to 2020, 31% since 2000, and 89% since the recent low in 2010. Not only does the U.S. have by far the highest overall firearm death rate among children, the U.S. also has the highest rates of each type of child firearm deaths — suicides, assaults, and accident or undetermined intent — among similarly large and wealthy countries.

  1. The U.S. also has a higher overall suicide rate (regardless of whether a firearm is involved) among peer nations.
  2. In the U.S., the overall child suicide rate is 3.6 per 100,000 children, and 1.7 per 100,000 children died by suicide from firearms.
  3. In comparable countries, on average, the overall child suicide rate is 2.8 per 100,000 children, and 0.2 per 100,000 children died by suicide from firearms.

If the U.S. child firearm suicide rate was brought down to 0.2 per 100,000 children (the same as the average in peer countries), 1,100 fewer children would have died in 2020 alone. Exposure and use of firearms also has implications for children’s mental health.

Data from CDC Wonder 2020 Underlying Cause of Death database and IHME Global Burden of Disease (GBD) 2019 study were used. Underlying cause of death categories are from IHME – GBD Level 3 Causes of Death. Top 20 leading causes of death among children ages 1-19 were ranked for the U.S. and comparable countries. These top 20 causes of death include: firearms, motor vehicle traffic, other injuries, congenital diseases, cancer, substance use disorders, cardiovascular diseases, infectious diseases, chronic respiratory diseases, respiratory infections, neurological disorders, diabetes and kidney diseases, maternal and neonatal complications, digestive diseases, nutritional deficiencies, HIV/AIDS and STIs, musculoskeletal disorders, skin and subcutaneous diseases, other mental disorders, and neglected tropical diseases. Unintentional firearm deaths include undetermined intent firearm deaths. Motor vehicle deaths include motor vehicle, pedestrian, other transport, being struck by or against a vehicle in traffic, and other land transport deaths. Other injuries encompass all injuries that are not from firearms, motor vehicles, or poisonings from substance use disorders, but not from injuries incurred via medical care. Cancer includes both malignant and in situ neoplasms. Congenital diseases include congenital malformations, deformations, and chromosomal disorders, as well as any disease/disorder that could not be identified via laboratory tests or examinations. Other mental disorders (not shown in the tables above but accounted for in analyses) include all deaths from mental health disorders, excluding suicide via firearm or other injury or poisonings via substance use disorder.

What is slow death disease?

Neurodegenerative diseases induce a slow form of cell death that is inconsistent with either apoptosis or necrosis. Hoshino et al. (page 589 ) describe a novel slow form of cell death caused by transcriptional repression, a dysfunction associated with neurons in the polyglutamine diseases.

Primary neurons grown in culture in the presence of α-amanitin, a chemical repressor of transcription, survived for five days, whereas treated nonneuronal cells underwent apoptotic death within 12 hours. When the neurons finally did die, their demise did not resemble apoptosis, necrosis, or autophagy, in terms of morphology, biochemical characteristics, or DNA breakdown.

YAP, a cotranscription factor that works with p73 to induce transcription of proapoptotic genes, was highly expressed in cells undergoing this slow transcriptional repression induced atypical death (TRIAD). However, the forms of YAP protein expressed in these neurons, YAPΔCs, lacked the transcriptional activation domain, and thus acted as dominant-negative mutants that blocked expression of target genes.

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SiRNAs directed against YAPΔCs led to rapid death in primary neurons exposed to α-amanitin, whereas overexpression of YAPΔCs protected nonneuronal cells from apoptosis triggers. YAPΔCs were detected in neurons in brain sections from wild-type and Huntington disease model mice, and in samples from the brains of human Huntington disease patients.

Relative to controls, mutant mice expressed a greater proportion of YAPΔCs versus full-length YAP. Moreover, overexpression of YAPΔCs slowed cell death in transgenic fly neurons expressing mutant huntingtin protein. Still not clear, however, is whether YAPΔCs slow down cell death in humans suffering from polyglutamine diseases.

Is there a disease that is 100% fatal?

List of human disease case fatality rates List of human disease case fatality rates Human may be characterized by their (CFR), the proportion of people diagnosed with a disease who die from it ( ). It should not be confused with the (IFR), the estimated proportion of people infected by a disease-causing agent, including asymptomatic and undiagnosed infections, who die from the disease.

Disease Type Treatment Notes Reference(s)
No cure 100%; invariably fatal Includes and all its variants,,, and others.
Viral Untreated ≈100% Preventable with vaccine and but, once the symptoms manifest, the CFR is almost always 100% fatal.
Parasitic Untreated ≈100%
Parasitic Untreated ≈100%
Amoebic infection No cure 90% 150 cases worldwide, only < 10 survivors have been identified.
Viral Untreated 90% : 1 
Amoebic infection No cure % Amphotericin B has shown efficacy in the limited survivorship population. Around 7 documented survivors
, Bacterial Untreated 95% The rate drops significantly to >50% with treatment.
– specifically the or type Viral Untreated ≈95% The rate drops significantly to 10% with effective treatments. : 28 
Bacterial Unvaccinated and untreated > 85% Early treatments lower the CFR to 45% as seen in the 2001 letter attacks.Monoclonal antibodies ( & ) could lower this further. : 88 
Viral Untreated ≈80% Early treatment including can improve prognosis.
, invasive pulmonary form Fungal Opportunistic w/, Tuberculosis and Immuno-compromised %
, Variola major – in pregnant women Viral Unvaccinated > 65% Eradicated. : 88 
Viral ≈60%
(Black fungus) Fungal %
, pneumonic Bacterial Untreated ≤ 60% : 78 
– specifically Viral Unvaccinated and untreated % Prognosis improved by early supportive treatments as seen in the and the,
– all outbreaks combined Viral Untreated % 23% in 1967 when it was first identified and 90% in 2004-2005 when the worst outbreak of the disease occurred. has shown promise in treating
Fungal Co-infection with HIV % 6 month mortality is >=60% with fluconazole-based therapy and 40% with amphotericin-based therapy in research studies in low and middle income countries.
Bacterial Unvaccinated and untreated > 50% : 27 
Bacterial Unvaccinated and untreated ≈100% : 58 
, Generalized Bacterial Unvaccinated and untreated 50% CFR drops to % with effective treatment.
Bacterial Vaccinated 43% Vaccines have been developed but have been frequently dismissed for having received controversial and improper testing on African populations.
Bacterial Unvaccinated and untreated % : 58 
Parasitic ≈40% With occurrence of Neural Larva Migrans; early, aggressive treatment necessary for survival, but only 2 full recoveries from NLM ever documented
Viral 36% may be a drug for HPS and HFRS but its effectiveness remains unknown, still, spontaneous recovery is possible with supportive treatment.
(MERS) Viral 34% has shown promise in treating
Viral ≈33%
Bacterial Unvaccinated and untreated % : 57 
Bacterial % : 27 
, Viral Unvaccinated 30% : 88 
, in newborns Viral Untreated ≈30% Where the mothers develop the disease between 5 days prior to, or 2 days after delivery. : 110 
Viral Untreated 26% Dengue haemorrhagic fever is also known as severe dengue,
Viral Untreated ≈21% has shown promise in treating
, typhoidal Bacterial Untreated % : 77 
Bacterial < % : 352 
Bacterial Unvaccinated and untreated %
Bacterial Unvaccinated and untreated % : 665 
Bacterial ≈15% : 665 
Viral 11% has shown promise in treating,
Parasitic Untreated ≈10%
Parasitic ≈10%
Bacterial toxin Treated < 10% Untreated foodborne botulism is thought to be ≈50%
, Bacterial Unvaccinated and untreated ≈%
Viral Unvaccinated 7.5%
, infants in developing countries Bacterial Unvaccinated ≈3.7% : 456 
, Viral Vaccinated 3% : 88 
, in Africa Bacterial ≈% With proper treatment, may be less than 1%, while without treatment may reach 50%
Viral Treated % varies with population, up to 22% in
Parasitic ≈2.4% From cases.
, in developing countries Viral Unvaccinated ≈% May reach % in some localities. : 431 
Bacterial Untreated ≤ 2% : 87 
, adults > 50 years old Viral Unvaccinated ≈1.8% : 278 
(COVID-19) Viral Unvaccinated & Treated with unspecific treatments 0.5-1% Depends largely on the age group of the person.
Viral Treated ≈1% 15% in hospitalized patients; higher in some epidemics.
Viral Unvaccinated ≈1% : 431 
, children in developing countries Bacterial Unvaccinated ≈1% For children 1–4 years old. : 456 
, Viral Unvaccinated 1% : 87–88 
Viral < 1% : 97–98 
Bacterial < 1% : 27 
Seasonal Influenza, Worldwide Viral Largely unvaccinated,Treated < 0.1–0.5% Depends largely on the age group of the people.
Parasitic ≈0.3%
Viral Unvaccinated % : 278 
Viral Without artificial breathing support ≈0.1%, varies by age: 2-5% for children and up to 15-30% for adults 0.5% of all infected become paralysed. Of those, about % die.
Viral ≈0.1%
Viral ≈0.1%
, Viral < 0.1%
, adults Viral Unvaccinated 0.02% : 110 
, children < 5 years old Viral 0.01%
, children Viral Unvaccinated 0.001% : 110 
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What is the number one cause of death for teenagers?

Leading causes of deaths among adolescents aged 15–19 years: Accidents (unintentional injuries) Homicide. Suicide.

Is the Black Death curable?

Treatment – Untreated pneumonic plague can be rapidly fatal, so early diagnosis and treatment is essential for survival and reduction of complications. Antibiotics and supportive therapy are effective against plague if patients are diagnosed in time. Pneumonic plague can be fatal within 18 to 24 hours of disease onset if left untreated, but common antibiotics for enterobacteria (gram negative rods) can effectively cure the disease if they are delivered early.

What is Black Death called today?

Understanding the Black Death – Today, scientists understand that the Black Death, now known as the plague, is spread by a bacillus called Yersinia pestis, (The French biologist Alexandre Yersin discovered this germ at the end of the 19th century.) They know that the bacillus travels from person to person through the air, as well as through the bite of infected fleas and rats.

  • Both of these pests could be found almost everywhere in medieval Europe, but they were particularly at home aboard ships of all kinds—which is how the deadly plague made its way through one European port city after another.
  • WATCH: How Rats and Fleas Spread the Black Death Not long after it struck Messina, the Black Death spread to the port of Marseilles in France and the port of Tunis in North Africa.

Then it reached Rome and Florence, two cities at the center of an elaborate web of trade routes. By the middle of 1348, the Black Death had struck Paris, Bordeaux, Lyon and London. Scroll to Continue Today, this grim sequence of events is terrifying but comprehensible.

Can Black Death start again?

The bottom line. New cases of the bubonic plague found in China are making headlines. But health experts say there’s no chance a plague epidemic will strike again, as the plague is easily prevented and cured with antibiotics.

What is the number 1 cause of death in the world?

The biggest causes of death in the US

Cause of death Total number of deaths Percentage of total deaths
1. Heart disease 696,962 20.6%
2. Cancer 602,350 17.8%
3. COVID-19 350,831 10.4%
4. Accidents (unintentional injuries) 200,955 5.9%